In the first presentation, Novalia Rachmawati, Ph.D., addressed the issue of histamine risks in Indonesian seafood through the research titled “Managing Histamine Risks in Indonesian Seafood: A Risk-Based Approach.” This result highlighted the formation of histamine, a naturally occurring toxin derived from histidine, which poses serious health risks when exceeding international safety standards ranging between 100–200 mg/kg, depending on the country. Novalia Rachmawati, Ph.D., explained that histamine poisoning, often mistaken for allergic reactions, can cause symptoms such as nausea, skin rashes, and respiratory discomfort. The presentation underscored the challenges faced by Indonesia’s seafood sector, particularly the rejection of export products due to histamine contamination, with tuna and mackerel identified as key carriers. Case studies revealed that improper handling and temperature abuse often lead to histamine levels surpassing acceptable limits in processed fish products. As a solution, Novalia Rachmawati, Ph.D., proposed a comprehensive risk-based framework that integrates assessment, management, and communication to mitigate histamine formation. In addition, the effectiveness of practical interventions has been demonstrated, such as maintaining low temperatures (10–15°C) and reducing salt content during processing, which have proven effective in minimizing risks.